FbxL4 polyclonal, anti-human, mouse, rat antibody
€310.00
In stock
SKU
AC-ABO11501
Catalog Number: AC-ABO11501
Size: 100 µg
Host: rabbit IgG
Applications: WB, IHC-P
Datasheet
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Size: 100 µg
Host: rabbit IgG
Applications: WB, IHC-P
Datasheet
Request Information
Description: Rabbit IgG polyclonal antibody for Macrophage migration inhibitory factor (MIF) detection. Tested with WB,IHC-P in human, mouse, rat.
Protein Name: Macrophage migration inhibitory factor(MIF)
Background:
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti- inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. .
Other Names:
Macrophage migration inhibitory factor, MIF, 5.3.2.1, Glycosylation-inhibiting factor, GIF, L-dopachrome isomerase, L-dopachrome tautomerase, 5.3.3.12, Phenylpyruvate tautomerase, MIF, GLIF, MMIF
Subcellular Localization: Secreted. Cytoplasm. Does not have a cleavable signal sequence and is secreted via a specialized, non- classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens.
Gene ID: 4282
Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human MIF(98-115aa NYYDMNAANVGWNNSTFA), different from the related rat and mouse sequences by one amino acid.
Calculated MW: 12476
Purification: Immunogen affinity purified.
Format: Lyophilized
Contents: Each vial contains 5mg BSA, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05 mg NaN3.
Concentration (mg/ml): Add 0.2 ml of distilled water will yield a concentration of 500 µg/ml.
Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.
Protein Name: Macrophage migration inhibitory factor(MIF)
Background:
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti- inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. .
Other Names:
Macrophage migration inhibitory factor, MIF, 5.3.2.1, Glycosylation-inhibiting factor, GIF, L-dopachrome isomerase, L-dopachrome tautomerase, 5.3.3.12, Phenylpyruvate tautomerase, MIF, GLIF, MMIF
Subcellular Localization: Secreted. Cytoplasm. Does not have a cleavable signal sequence and is secreted via a specialized, non- classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens.
Gene ID: 4282
Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human MIF(98-115aa NYYDMNAANVGWNNSTFA), different from the related rat and mouse sequences by one amino acid.
Calculated MW: 12476
Purification: Immunogen affinity purified.
Format: Lyophilized
Contents: Each vial contains 5mg BSA, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05 mg NaN3.
Concentration (mg/ml): Add 0.2 ml of distilled water will yield a concentration of 500 µg/ml.
Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.
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