FBXO32 Polyclonal Antibody

Background:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms:
4833442G10Rik, AI430017, Atrogin 1 , Atrogin-1, ATROGIN1, Atrophy gene 1, F box only protein 32, F-box only protein 32, F-box protein 32, FBX32, fbxo25, FBXO32, FLJ32424, MAFbx, MGC108443, MGC137646, MGC33610 , Muscle atrophy F box, Muscle atrophy F box protein, Muscle atrophy F-box protein

Immunogen: Synthetic peptide of human FBXO32

Swissprot: Q969P5
Gene Accession: NP478136

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.98 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.