FBXW7 polyclonal (N-term), anti-human
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In stock
SKU
AC-AP21312a
Catalog Number: AC-AP21312a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB52458
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB52458
Applications: WB
Datasheet
Request Information
Background:
Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
Other Names:
F-box/WD repeat-containing protein 7, Archipelago homolog, hAgo, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, hCdc4, FBXW7 (HGNC:16712)
Target/Specificity:
This FBXW7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 133-167 amino acids from the N-terminal region of human FBXW7.
Gene Name: FBXW7 (HGNC:16712)
Gene ID: 55294
Primary Accession: Q969H0
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
Other Names:
F-box/WD repeat-containing protein 7, Archipelago homolog, hAgo, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, hCdc4, FBXW7 (HGNC:16712)
Target/Specificity:
This FBXW7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 133-167 amino acids from the N-terminal region of human FBXW7.
Gene Name: FBXW7 (HGNC:16712)
Gene ID: 55294
Primary Accession: Q969H0
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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