CD89 (FCAR) polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60015
Background:
Fc (Ig constant fragment) receptors ensure protection of the host against foreign antigens, such as microorganisms and pathogens, by removing Ig-coated antigen complexes from circulation. Fc receptors are present on lymphoid and myeloid derivatives, where they mediate endocytosis of Ig-antigen complexes, antibody production in B cells through T cell antigen presentation, cytotoxicity, and the release of cytokines and reactive oxygen species. Human myeloid receptor for the Fc fragment of IgA (CD89) is a glycoprotein that is expressed on the surface of neutrophils, monocytes, macrophages and eosinophils and is a potent cytotoxic trigger molecule. Cytokines can initiate a highbinding state for CD89 through a mechanism that involves the intracellular C-terminus of CD89.
Alternative Name:
Immunoglobulin alpha Fc receptor, IgA Fc receptor, FCAR, CD89
Application Dilution: WB: 1:500~1:1000
Specificity: FCAR polyclonal antibody detects endogenous levels of FCAR protein.
Immunogen:
A synthetic peptide corresponding to residues in Human FCAR
MW: ~ 60 kDa
Swis Prot.: P24071
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Fc (Ig constant fragment) receptors ensure protection of the host against foreign antigens, such as microorganisms and pathogens, by removing Ig-coated antigen complexes from circulation. Fc receptors are present on lymphoid and myeloid derivatives, where they mediate endocytosis of Ig-antigen complexes, antibody production in B cells through T cell antigen presentation, cytotoxicity, and the release of cytokines and reactive oxygen species. Human myeloid receptor for the Fc fragment of IgA (CD89) is a glycoprotein that is expressed on the surface of neutrophils, monocytes, macrophages and eosinophils and is a potent cytotoxic trigger molecule. Cytokines can initiate a highbinding state for CD89 through a mechanism that involves the intracellular C-terminus of CD89.
Alternative Name:
Immunoglobulin alpha Fc receptor, IgA Fc receptor, FCAR, CD89
Application Dilution: WB: 1:500~1:1000
Specificity: FCAR polyclonal antibody detects endogenous levels of FCAR protein.
Immunogen:
A synthetic peptide corresponding to residues in Human FCAR
MW: ~ 60 kDa
Swis Prot.: P24071
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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