FER polyclonal, anti-human, rat

Quantity: 100 µg

Background:
FER(FPS/FES-Related tyrosine kinase) also known as TYK3, is an enzyme that in humans is encoded by the FER gene. Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. By in situ hybridization, Morris et al.(1990) concluded that the FER gene is located at 5q21-q22. Treatment of cells with JMP resulted in the release of FER from the cadherin complex and its accumulation in the integrin complex. The accumulation of FER in the integrin complex and the inhibitory effects of JMP could be reversed with a peptide that mimics the first coiled-coil domain of FER. The results suggested that FER mediates crosstalk between CDH2 and ITGB1. In Fer mutant mice, leukocyte emigration was exaggerated in response to LPS without altering vascular permeability, suggesting that FER has a role in regulating innate immunity.

Description:
Rabbit IgG polyclonal antibody for Tyrosine-protein kinase Fer (FER) detection. Tested with WB, IHC-P in Human, Rat.

Synonyms:
c FER antibody, Fer(fps/fes related) tyrosine kinase(phosphoprotein NCP94) antibody, Fer(fps/fes related) tyrosine kinase antibody, FER antibody, FER_HUMAN antibody, p94 FER antibody, p94-FER antibody, Phosphoprotein NCP94 antibody, Proto oncogene tyrosine protein kinase FER antibody, Proto-oncogene c-Fer antibody, TYK3 antibody, Tyrosine kinase 3 antibody, Tyrosine-protein kinase Fer antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human FER(521-536aa FSNIPQLIDHHYTTKQ), different from the related rat and mouse sequences by two amino acids.A synthetic peptide corresponding to a sequence in the middle region of human FER(521-536aa FSNIPQLIDHHYTTKQ), different from the related rat and mouse sequences by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.