FERMT2 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS71838
Background:
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.
Alternative Name:
KIND2, MIG2, PLEKHC1, UNC112, UNC112B, mig-2, Fermitin family homolog 2, Kindlin-2, Kindlin2, Kindlin 2, Fermitin 2, Fermitin 2, Fermitin -2
Application Dilution: WB: 1:1000 - 1:2000
Specificity: FERMT2 polyclonal antibody detects endogenous levels of FERMT2 protein.
Immunogen:
Recombinant protein of human FERMT2
MW: 78kDa
Swis Prot.: Q96AC1
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.
Alternative Name:
KIND2, MIG2, PLEKHC1, UNC112, UNC112B, mig-2, Fermitin family homolog 2, Kindlin-2, Kindlin2, Kindlin 2, Fermitin 2, Fermitin 2, Fermitin -2
Application Dilution: WB: 1:1000 - 1:2000
Specificity: FERMT2 polyclonal antibody detects endogenous levels of FERMT2 protein.
Immunogen:
Recombinant protein of human FERMT2
MW: 78kDa
Swis Prot.: Q96AC1
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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