Ferritin Heavy Chain polyclonal, anti-human, mouse, rat

Background:
 ,Mammalian ferritins consist of 24 subunits made up of two types of poly-peptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of FeII, whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of FeIII. The most prominent role of mamma-lian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of aging-related cataracts. ,

Alternative Name:
Ferritin H subunit, FTH1, FTH, FTHL6, Apoferritin, Cell proliferation inducing gene 15 protein, Cell proliferation-inducing gene 15 protein, F HC, Ferritin H subunit, Ferritin heavy chain, Ferritin heavy polypeptide 1, FHC, FRIH, FRIH, FTH 1, FTH, FTH1, FTH1 protein, FTHL 6, FTHL6, Iron overload autosomal dominant, MGC104426, N-terminally processed, OK/SW-cl.84, PIG 15, PIG15, Placenta immunoregulatory factor, PLIF, Proliferation inducing gene 15 protein, Proliferation inducing protein 15,

Application Dilution:
WB:1:500-1:1,000
IHC:1:50-1:200
ICC:1:50-1:200

Specificity: Ferritin Heavy Chain polyclonal antibody detects endogenous levels of Ferritin Heavy Chain protein.

Immunogen:
Recombinant protein

MW: 21 kDa

Swiss-Prot: P02794(Human) P09528(Mouse) P19132(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or  ,-80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.