FFAR1 N-terminal region polyclonal, anti-human, mouse, rat, pig, bovine, dog

Background:
G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.

Other Names:
Free fatty acid receptor 1, G-protein coupled receptor 40, FFAR1, GPR40

Immunogen:
The immunogen for anti-FFAR1 antibody: synthetic peptide directed towards the N terminal of human FFAR1

Gene Name:
FFAR1
Gene Name:
2864
NCBI Accession:
NP_005294
Primary Accession: O14842
Other Accession: NM_005303;NP_005294
Purification: Affinity Purified
Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.