FGFR1 (C-term Y730) Blocking peptide
€363.00
In stock
SKU
AC-BP19436b
Background:
The protein encoded by this gene is a member of thefibroblast growth factor receptor (FGFR) family, where amino acidsequence is highly conserved between members and throughoutevolution. FGFR family members differ from one another in theirligand affinities and tissue distribution. A full-lengthrepresentative protein consists of an extracellular region,composed of three immunoglobulin-like domains, a single hydrophobicmembrane-spanning segment and a cytoplasmic tyrosine kinase domain.The extracellular portion of the protein interacts with fibroblastgrowth factors, setting in motion a cascade of downstream signals,ultimately influencing mitogenesis and differentiation. Thisparticular family member binds both acidic and basic fibroblastgrowth factors and is involved in limb induction. Mutations in thisgene have been associated with Pfeiffer syndrome, Jackson-Weisssyndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, andautosomal dominant Kallmann syndrome 2. Chromosomal aberrationsinvolving this gene are associated with stem cellmyeloproliferative disorder and stem cell leukemia lymphomasyndrome. Alternatively spliced variants which encode differentprotein isoforms have been described; however, not all variantshave been fully characterized.
Other Names:
Fibroblast growth factor receptor 1, FGFR-1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr, CD331, FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
Gene Name: FGFR1
Gene ID: 2260
Primary Accession: P11362
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is a member of thefibroblast growth factor receptor (FGFR) family, where amino acidsequence is highly conserved between members and throughoutevolution. FGFR family members differ from one another in theirligand affinities and tissue distribution. A full-lengthrepresentative protein consists of an extracellular region,composed of three immunoglobulin-like domains, a single hydrophobicmembrane-spanning segment and a cytoplasmic tyrosine kinase domain.The extracellular portion of the protein interacts with fibroblastgrowth factors, setting in motion a cascade of downstream signals,ultimately influencing mitogenesis and differentiation. Thisparticular family member binds both acidic and basic fibroblastgrowth factors and is involved in limb induction. Mutations in thisgene have been associated with Pfeiffer syndrome, Jackson-Weisssyndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, andautosomal dominant Kallmann syndrome 2. Chromosomal aberrationsinvolving this gene are associated with stem cellmyeloproliferative disorder and stem cell leukemia lymphomasyndrome. Alternatively spliced variants which encode differentprotein isoforms have been described; however, not all variantshave been fully characterized.
Other Names:
Fibroblast growth factor receptor 1, FGFR-1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr, CD331, FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
Gene Name: FGFR1
Gene ID: 2260
Primary Accession: P11362
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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