FGFR1-Y307 polyclonal, anti-human
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In stock
SKU
AC-AP9814A
Catalog Number: AC-AP9814A
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB10987
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB10987
Applications: WB
Datasheet
Request Information
Background:
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
Other Names:
Fibroblast growth factor receptor 1, FGFR-1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr, CD331, FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
Target/Specificity:
This FGFR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-314 amino acids from human FGFR1.
Antigen Region:
285-314
Antigen Type: Synthetic Peptide
Gene Name: FGFR1
Gene ID: 2260
Primary Accession: P11362
NCBI Accession: NP_001167534.1;NP_001167535.1;NP_001167536.1;NP_001167537.1;NP_001167538.1;NP_056934.2;NP_075593.1;NP_075594.1;NP_075598.2
Other Accession: P16092; P21804
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
Other Names:
Fibroblast growth factor receptor 1, FGFR-1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr, CD331, FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
Target/Specificity:
This FGFR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-314 amino acids from human FGFR1.
Antigen Region:
285-314
Antigen Type: Synthetic Peptide
Gene Name: FGFR1
Gene ID: 2260
Primary Accession: P11362
NCBI Accession: NP_001167534.1;NP_001167535.1;NP_001167536.1;NP_001167537.1;NP_001167538.1;NP_056934.2;NP_075593.1;NP_075594.1;NP_075598.2
Other Accession: P16092; P21804
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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