FGFR4 polyclonal, anti-human
€0.00
In stock
SKU
AC-AP7639d
Catalog Number: AC-AP7639d
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB14736
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB14736
Applications: WB
Datasheet
Request Information
Background:
FGFR4 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for family members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
Other Names:
Fibroblast growth factor receptor 4, FGFR-4, CD334, FGFR4, JTK2, TKF
Target/Specificity:
This FGFR4 antibody is generated from rabbits immunized with recombinant human FGFR4 protein.
Antigen Type: Recombinant Protein
Gene Name: FGFR4
Gene ID: 2264
Primary Accession: P22455
NCBI Accession: NP_002002.3;NP_075252.2;NP_998812.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
FGFR4 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for family members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
Other Names:
Fibroblast growth factor receptor 4, FGFR-4, CD334, FGFR4, JTK2, TKF
Target/Specificity:
This FGFR4 antibody is generated from rabbits immunized with recombinant human FGFR4 protein.
Antigen Type: Recombinant Protein
Gene Name: FGFR4
Gene ID: 2264
Primary Accession: P22455
NCBI Accession: NP_002002.3;NP_075252.2;NP_998812.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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