FGFRL1 Polyclonal Antibody

Background:
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Research Area: Signal Transduction

Synonyms:
FGF homologous factor receptor, FGF receptor like protein 1, FGF receptor-like protein 1, FGFR 5, FGFR like protein, FGFR-5, FGFR-like protein, FGFR5, Fgfrl1, FGRL1, FHFR, Fibroblast growth factor receptor 5, Fibroblast growth factor receptor like 1, Fibroblast growth factor receptor-like 1

Immunogen: Recombinant protein of human FGFRL1

Swissprot: Q8N441
Gene Accession: NP_068742

Calculated MW: 55 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: WB 1:200-1:1000, IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-18635/sc-18637/sc-50326