FGR polyclonal, anti-human

Background:
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Synonyms: SRC2, c-fgr, c-src2, p55-Fgr, p55c-fgr, p58-Fgr, p58c-fgr

Cellular Location: Cell membrane Cell projection Cytoplasm Cytoplasmic side Lipid-anchor Mitochondrion inner membrane Mitochondrion intermembrane space Peripheral membrane protein cytoskeleton cytosol ruffle membrane

Immunogen:
A synthetic peptide of human FGR

Gene Symbol: FGR

Gene ID: 2268

Swiss prot: P09769

Calculated MW: 59kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.