FH monoclonal (N-term) (Ascites), anti-human

Background:
The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.

Other Names:
Fumarate hydratase, mitochondrial, Fumarase, FH

Target/Specificity:
This FH antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 35-63 amino acids from the N-terminal region of human FH.

Antigen Region:
35-63

Antigen Type: Synthetic Peptide

Gene Name: FH {ECO:0000303|PubMed:27037871, ECO:0000312|HGNC:HGNC:3700}
Gene ID: 2271
Primary Accession: P07954
NCBI Accession: NP_000134.2
Other Accession: P14408; P10173; Q60HF9; NP_000134.2
Format: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.