FH Polyclonal Antibody

Background:
The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.

Research Area: Cancer, Metabolism, Signal Transduction

Synonyms:
FH, Fumarase, Fumarate hydratase, Fumarate hydratase mitochondrial, Fumarate hydratase, mitochondrial, FUMH, HLRCC, LRCC, MCL, MCUL 1, MCUL1, MS709, Multiple hereditary cutaneous leiomyomata

Immunogen: Recombinant protein of human FH

Swissprot: P07954
Gene Accession: BC003108

Calculated MW: 55 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.5 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-100743