FH polyclonal (N-term), anti-human
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In stock
SKU
AC-AP18400a
Catalog Number: AC-AP18400a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB38443
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB38443
Applications: WB
Datasheet
Request Information
Background:
The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.
Other Names:
Fumarate hydratase, mitochondrial, Fumarase, FH
Target/Specificity:
This FH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-135 amino acids from the N-terminal region of human FH.
Antigen Region:
107-135
Antigen Type: Synthetic Peptide
Gene Name: FH {ECO:0000303|PubMed:27037871, ECO:0000312|HGNC:HGNC:3700}
Gene ID: 2271
Primary Accession: P07954
NCBI Accession: NP_000134.2
Other Accession: P14408; P10173; P97807; Q60HF9; NP_000134.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.
Other Names:
Fumarate hydratase, mitochondrial, Fumarase, FH
Target/Specificity:
This FH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-135 amino acids from the N-terminal region of human FH.
Antigen Region:
107-135
Antigen Type: Synthetic Peptide
Gene Name: FH {ECO:0000303|PubMed:27037871, ECO:0000312|HGNC:HGNC:3700}
Gene ID: 2271
Primary Accession: P07954
NCBI Accession: NP_000134.2
Other Accession: P14408; P10173; P97807; Q60HF9; NP_000134.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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