FHIT polyclonal, anti-human

Quantity: 100 µg

Background:
Bis(5'-adenosyl)-triphosphatase, also known as fragile histidine triad protein (FHIT) is an enzyme that in humans is encoded by the FHIT gene. This gene, a member of the histidine triad gene family, encodes a diadenosine P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3p14.2, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Furthermore, FHIT has been shown to synergize with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer. It also acts as a tumor suppressor of HER2/neu driven breast cancer.

Description:
Rabbit IgG polyclonal antibody for Bis (5'-adenosyl)-triphosphatase (FHIT) detection. Tested with WB, IHC-P in Human.

Synonyms:
AP3A hydrolase antibody, AP3A hydrolase fragile site 3p14.2 antibody, AP3Aase antibody, Bis 5' adenosyl triphosphatase antibody, Bis(5' adenosyl) triphosphatase antibody, Diadenosine 5' 5''' P1 P3 triphosphate hydrolase antibody, Dinucleosidetriphosphatase antibody, FRA 3B antibody, FRA3B antibody, Fragile histidine triad antibody, Fragile histidine triad gene antibody, Fragile histidine triad protein antibody, Tumor suppressor protein antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human FHIT recombinant protein (Position: M1-Q147). Human FHIT shares 90% and 87% amino acid (aa) sequences identity with mouse and rat FHIT, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.