Fibrinogen Gamma Chain Dodecapeptide
€118.00
In stock
SKU
350172
Protein Family: CAM Ligands, Cell Adhesion Molecules
Pathway and Disease: Immune System
Alternate Names: Fibrinogen gamma chain; FGG; Fibrinogen gamma-chain dodecapeptide
Accession No.: P02679
Description:
The dodecapeptide corresponds to the C-term end of fibrinogen gamma chain responsible of platelet aggregation. The fibrinogen gamma-chain dodecapeptide inhibits agonist-induced platelet aggregation by competing with fibrinogen for binding to platelet integrin receptor GPIIb/IIIa (glycoprotein IIb-IIIa), also known as integrin alphaIIb-beta3. This peptide exhibits hemostatic, pro-thrombotic activity and enhancing thrombus formation. It is clinically used as a platelet substitute.
Format:
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.
MW: 1189.29 g/mol
Sequence:
H-His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val-OH or H-HHLGGAKQAGDV-OH
Composition:
C50H80N18O16
Purity:
> 95% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.
Pathway and Disease: Immune System
Alternate Names: Fibrinogen gamma chain; FGG; Fibrinogen gamma-chain dodecapeptide
Accession No.: P02679
Description:
The dodecapeptide corresponds to the C-term end of fibrinogen gamma chain responsible of platelet aggregation. The fibrinogen gamma-chain dodecapeptide inhibits agonist-induced platelet aggregation by competing with fibrinogen for binding to platelet integrin receptor GPIIb/IIIa (glycoprotein IIb-IIIa), also known as integrin alphaIIb-beta3. This peptide exhibits hemostatic, pro-thrombotic activity and enhancing thrombus formation. It is clinically used as a platelet substitute.
Format:
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.
MW: 1189.29 g/mol
Sequence:
H-His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val-OH or H-HHLGGAKQAGDV-OH
Composition:
C50H80N18O16
Purity:
> 95% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.
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