Fibrinogenγ polyclonal, anti-human

Background:
Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

Alternative Name:
FGG, FGG, FIBG, Fibrinogen gamma chain, Fibrinogen gamma polypeptide, fibrinogen gamma-b chain,

Application Dilution:
WB:1:5,000-1:10,000
IHC:1:50-1:200
FC:1:50-1:100

Specificity: Fibrinogenγ polyclonal antibody detects endogenous levels of Fibrinogenγ protein.

MW: 52 kDa

Swiss-Prot: P02679(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.