Fibulin 3 polyclonal, anti-human, mouse, rat

Protein Family: Cell Adhesion Molecules

Pathway and Disease: Cancers, Cell Motility, Nervous and Sensory Systems, Signaling Molecules and Interaction

Description:
Fibulin 3, also known as epidermal growth factor (EGF)-containing fibulin-like extracellular matrix protein 1 (EFEMP1), is a member of the fibulin family of extracellular glycoproteins, a group of proteins that are widely distributed and frequently associated with vascular and elastic tissues. The fibulin proteins typically contain a tandem array of EGF-like repeats and a fibulin-type COOH-terminal module. Aberrant accumulation of Fibulin 3 in the endoplasmic reticulum of retinal pigment epithelial cells has been shown to be associated with inherited forms of macular degeneration, but the loss of Fibulin 3 expression does not lead to macular degeneration but rather the appearance of hernias due to a reduction of elastic fibers of fascial connective tissue. Recent experiments have shown that expression of Fibulin 3 promotes tumor growth and may thus be a therapeutic target. At least three isoforms of Fibulin 3 are known to exist. This antibody is predicted to not cross-react with other Fibulin proteins.

Alternate Names: Fibulin 3, FBLN3, EGF-containing fibulin-like extracellular matrix protein 1, EFEMP1, DHRD, DRAD, FBNL, MLVT, MTLV, S1-5, FIBL-3

Application Notes: E: 1:500-1:1,000; WB: 1:1,000-1:2,000; ICC: 1:50-1:200; IF: 1:50-1:200

Accession No.: NP_004096

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Fibulin 3.

Format: Each vial contains 0.1 mg IgG (1 mg/ml) in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.