Fibulin 5 polyclonal, anti-human, mouse, rat

Background:
Fibulin proteins contribute to normal development of elastic fiber systems in various types of organs that require elasticity, such as vasculature, lung and skin. Fibulin-5 (EVEC, UP50, DANCE) is an integrin-binding extracellular matrix protein that mediates endothelial cell adhesion. Fibulin-5 is also a calcium-dependent elastin-binding protein that scaffolds cells to elastic fibers, thereby preventing elastinopathy in the skin, lung, and vasculature. The Arg-Gly-Asp (RGD) motif in Fibulin-5 interacts with cell surface integrins avb3, avb5 and a9b1, serves as an anchorage for elastic fibers to cells, and promotes organization of elastic fibers. The human Fibulin-5 gene maps to chromosome 14q32.12 and encodes a 488 amino acid protein.

Alternative Name:
FIBL-5, Dance, UP50, FBLN5, DANCE, ADCL2, ARCL1A, ARMD3, Dance, Developmental arteries and neural crest EGF like protein, Developmental arteries and neural crest EGF-like protein, EVEC, Fbln5, FBLN5, FIBL 5, FIBL-5, Fibulin-5, FLJ90059, UP50, Urine p50 protein,

Application Dilution:
WB:1:1,000-1:2,000
ICC:1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: Fibulin 5 polyclonal antibody detects endogenous levels of Fibulin 5 protein.

Immunogen:
Recombinant protein within human Fibulin 5 210-360 aa.

MW: 50 kDa

Swiss-Prot: Q9UBX5(Human) Q9WVH9(Mouse) Q9WVH8(Rat)

Purification & Purity:
Protein affinity purified.

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.