FKBP38 polyclonal, anti-human, mouse, rat antibody
€275.00
In stock
SKU
AC-ABV10503-100
Catalog Number: AC-ABV10503-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
FK506-binding protein 38 (FKBP38), a member of the immunophilin family, has been implicated to play an important role in apoptosis thro µgh its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP38 by RNAi or transfection of a mutant FKBK38 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been s µggested that FKBP38 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation thro µgh interactions with tuberous sclerosis genes.
Other Names:
FKBPR38 , FKBP8 , FKBP 8 , FK506 binding protein 8 , FKBP 38
Primary Accession: O35465
Other Accession: AY225340
Gene Name: Fkbp8
Gene ID: 14232
Concentration (mg/ml): 0.2 mg/ml
FK506-binding protein 38 (FKBP38), a member of the immunophilin family, has been implicated to play an important role in apoptosis thro µgh its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP38 by RNAi or transfection of a mutant FKBK38 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been s µggested that FKBP38 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation thro µgh interactions with tuberous sclerosis genes.
Other Names:
FKBPR38 , FKBP8 , FKBP 8 , FK506 binding protein 8 , FKBP 38
Primary Accession: O35465
Other Accession: AY225340
Gene Name: Fkbp8
Gene ID: 14232
Concentration (mg/ml): 0.2 mg/ml
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