FLNB polyclonal, anti-human, mouse, rat

Background:
This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Synonyms: ABP-278, ABP-280, AOI, FH1, FLN-B, FLN1L, LRS1, SCT, TABP, TAP

Cellular Location: Cytoplasm Z line cell cortex cytoskeleton myofibril sarcomere

Immunogen:
Recombinant protein of human FLNB

Gene Symbol: FLNB

Gene ID: 2317

Swiss prot: O75369

Calculated MW: 278kDa

Recommended dilution:
WB 1:500-1000, IHC 1:50-100, IF 1:20-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.