FLT3 polyclonal, anti-human, mouse

Background:
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Synonyms: FLK2, STK1, CD135, FLK-2

Cellular Location: Cell membrane

Immunogen:
Recombinant protein of human FLT3

Gene Symbol: FLT3

Gene ID: 2322

Swiss prot: P36888

Calculated MW: 113kDa

Recommended dilution:
WB 1:500-2000, IHC 1:20-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.