FLT3 (Tyr589/591) Antibody Blocking peptide
€363.00
In stock
SKU
AC-BP11143a
Background:
This gene encodes a class III receptor tyrosine kinasethat regulates hematopoiesis. The receptor consists of anextracellular domain composed of five immunoglobulin-like domains,one transmembrane region, and a cytoplasmic kinase domain splitinto two parts by a kinase-insert domain. The receptor is activatedby binding of the fms-related tyrosine kinase 3 ligand to theextracellular domain, which induces homodimer formation in theplasma membrane leading to autophosphorylation of the receptor. Theactivated receptor kinase subsequently phosphorylates and activatesmultiple cytoplasmic effector molecules in pathways involved inapoptosis, proliferation, and differentiation of hematopoieticcells in bone marrow. Mutations that result in the constitutiveactivation of this receptor result in acute myeloid leukemia andacute lymphoblastic leukemia.
Other Names:
Receptor-type tyrosine-protein kinase FLT3, FL cytokine receptor, Fetal liver kinase-2, FLK-2, Fms-like tyrosine kinase 3, FLT-3, Stem cell tyrosine kinase 1, STK-1, CD135, FLT3, CD135, FLK2, STK1
Gene Name: FLT3
Gene ID: 2322
Primary Accession: P36888
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a class III receptor tyrosine kinasethat regulates hematopoiesis. The receptor consists of anextracellular domain composed of five immunoglobulin-like domains,one transmembrane region, and a cytoplasmic kinase domain splitinto two parts by a kinase-insert domain. The receptor is activatedby binding of the fms-related tyrosine kinase 3 ligand to theextracellular domain, which induces homodimer formation in theplasma membrane leading to autophosphorylation of the receptor. Theactivated receptor kinase subsequently phosphorylates and activatesmultiple cytoplasmic effector molecules in pathways involved inapoptosis, proliferation, and differentiation of hematopoieticcells in bone marrow. Mutations that result in the constitutiveactivation of this receptor result in acute myeloid leukemia andacute lymphoblastic leukemia.
Other Names:
Receptor-type tyrosine-protein kinase FLT3, FL cytokine receptor, Fetal liver kinase-2, FLK-2, Fms-like tyrosine kinase 3, FLT-3, Stem cell tyrosine kinase 1, STK-1, CD135, FLT3, CD135, FLK2, STK1
Gene Name: FLT3
Gene ID: 2322
Primary Accession: P36888
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
| Is Featured? | No |
|---|
Write Your Own Review