FNTB polyclonal, anti-human, rat

Background:
Mammalian protein farnesyl transferases are heterodimeric proteins containing two nonidentical α and β subunits that attach farnesyl residues to a cysteine at the fourth position from the COOH terminus of several proteins, including nuclear lamins and p21Ras proteins. The natural substrates contain the Cys-A-A-Xaa recognition sequence, where the A residues are aliphatic and Xaa represents methionine, serine, glutamine or cysteine. The purified farnesyl transferase is an a-b heterodimer. The β subunit, which is known as FTβ, CAAX farnesyltransferase subunit β, or Ras proteins prenyltransferase subunit β, is a 437 amino acid protein that contains five PFTB repeats and binds the peptide substrate. The α subunit is suspected to participate in formation of a stable complex with the substrate farnesyl pyrophosphate.

Alternative Name:
FTase-beta, FNTB, CAAX farnesyltransferase subunit beta, EC 2.5.1.58, EC=2.5.1.58, Farnesyltransferase, farnesyltransferase CAAX box beta1, farnesyltransferase, CAAX box, beta, FNTB, FNTB, FPTB, FTase beta, FTase-beta, MGC105303, Protein farnesyltransferase subunit beta, RAS proteins prenyltransferase beta, Ras proteins prenyltransferase subunit beta,

Application Dilution:
WB:1:1,000-1:2,000
ICC:1:50-1:200

Specificity: FNTB polyclonal antibody detects endogenous levels of FNTB protein.

Immunogen:
recombinant protein

MW: 43 kDa

Swiss-Prot: P49356(Human) Q02293(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.