FosB polyclonal, anti-human, mouse, rat

Background:
The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos B include Fra-1 and Fra-2 genes.

Alternative Name:
FOSB, Activator protein 1, AP 1, DKFZp686C0818, FBJ murine osteosarcoma viral oncogene homolog B, fosB, FOSB, G0/G1 switch regulatory protein 3, G0S3, GOS 3, GOS B, GOS3, GOSB, MGC42291, Oncogene FOS B, Oncogene FOSB, Protein fos B, Protein fosB,

Application Dilution:
WB:1:1,000
ICC:1:50-1:200
IHC:1:50-1:200

Specificity: FosB polyclonal antibody detects endogenous levels of FosB protein.

Immunogen:
recombinant protein

MW: 48 kDa

Swiss-Prot: P53539(Human) P13346(Mouse) EntrezGene:100360880(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.