FOXA2 polyclonal, anti-human

Background:
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs, FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis, regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

Alternative Name:
HNF-3-beta, HNF-3B, TCF-3B, FOXA2, Forkhead box A2, Forkhead box protein A2, FOX A2, foxa2, FOXA2, Hepatic nuclear factor 3 beta, Hepatocyte nuclear factor 3, Hepatocyte nuclear factor 3 beta, Hepatocyte nuclear factor 3-beta, HNF 3B, HNF-3-beta, HNF-3B, HNF3B, MGC19807, TCF 3B, TCF-3B, TCF3B, Transcription factor 3B,

Application Dilution:
WB:1:1,000-1:5,000
ICC:1:50-1:200

Specificity: FOXA2 polyclonal antibody detects endogenous levels of FOXA2 protein.

Immunogen:
recombinant protein

MW: 52 kDa

Swiss-Prot: Q9Y261(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.