FOXL2 Polyclonal Antibody

Background:
This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
Blepharophimosis, Blepharophimosis epicanthus inversus and ptosis 1, Blepharophimosis epicanthus inversus and ptosis, BPES 1, BPES, BPES1, Epicanthus inversus and ptosis 1, Forkhead box L2, Forkhead box protein L2, Forkhead transcription factor FOXL2, FOX L2, FOXL 2, FOXL2, FOXL2, PFRK, PINTO, PITUITARY FORKHEAD FACTOR, POF 3, POF3

Immunogen: Synthetic peptide of human FOXL2

Swissprot: P58012
Gene Accession: NP_075555

Calculated MW: 50 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.5 mg/mL
Dilution: WB 1:500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-55655/sc-55657/sc-68348