FOXM1 polyclonal, anti-human

Quantity: 100 µg

Background:
Forkhead box protein M1, also called FOXM1, is a protein that in humans is encoded by the FOXM1 gene. It is mapped to 12p13.33. The protein encoded by this gene is a member of the FOX family of transcription factors. FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases and also in the control of cell proliferation. FOXM1 gene is now known as a human proto-oncogene. Abnormal upregulation of FOXM1 is involved in the oncogenesis of basal cell carcinoma, the most common human cancer worldwide. It was hypothesized that FOXM1 induces cancer initiation through stem/progenitor cell expansion. What's more, FOXM1 has been shown to modulate the epigenome. It was found that overexpression of FOXM1 "brain washes" normal cells to adopt cancer-like epigenome.

Description:
Rabbit IgG polyclonal antibody for Forkhead box protein M1 (FOXM1) detection. Tested with WB in Human.

Synonyms:
FKHL16 antibody, Forkhead box M1 antibody, Forkhead box protein M1 antibody, forkhead like 16 antibody, Forkhead-related protein FKHL16 antibody, FOX M1 antibody, Foxm1 antibody, FOXM1_HUMAN antibody, FOXM1B antibody, Hepatocyte nuclear factor 3 forkhead homolog 11 antibody, HFH-11 antibody, HFH11 antibody, HNF-3/fork-head homolog 11 antibody, HNF3 antibody, INS1 antibody, M phase phosphoprotein 2 antibody, M-phase phosphoprotein 2 antibody, MPHOSPH2 antibody, MPM 2 antibody, MPM-2 reactive phosphoprotein 2 antibody, MPM2 reactive phosphoprotein 2 antibody, MPP2 antibody, PIG29 antibody, TGT3 antibody, Transcription factor Trident antibody, Trident antibody, WIN antibody, Winged-helix factor from INS-1 cells antibody, Winged-helix factor from INS1 cells antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human FOXM1 recombinant protein (Position: A411-Q763). Human FOXM1 shares 75% and 76% amino acid (aa) sequences identity with mouse and rat FOXM1, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.