FOXO3a polyclonal, anti-human, mouse antibody
€275.00
In stock
SKU
AC-ABV10509-100
Catalog Number: AC-ABV10509-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB, IP
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB, IP
Datasheet
Request Information
Background:
Mammalian forkhead members of the class O (FOXO) transcription factors, including FOXO1, FOXO3a, and FOXO4, are implicated in the regulation of a variety of cellular processes, including the cell cycle, apoptosis, DNA repair, stress resistance, and metabolism. FOXO proteins are negatively regulated by the phosphatidylinositol 3-kinase-Akt signaling pathway, which is activated by growth factors and cytokines. Recent studies indicate that the activities of FOXO proteins are also regulated by oxidative stress, which induces their phosphorylation, translocation to the nucleus, and acetylation-deacetylation. Similar to the tumor suppressor p53, FOXO is activated by stress and induces the expression of genes that contribute to cell-cycle arrest, s µggesting that it also functions as a tumor suppressor.
Other Names:
FOXO3A , 602681 , O43524 , AF6q21 , DKFZp781A0677 , FKHRL1 , FKHRL1P2 , MGC12739 , MGC31925
Primary Accession: O43524
Gene Name: FOXO3 (HGNC:3821)
Gene ID: 2309
Concentration (mg/ml): 0.2 mg/ml
Mammalian forkhead members of the class O (FOXO) transcription factors, including FOXO1, FOXO3a, and FOXO4, are implicated in the regulation of a variety of cellular processes, including the cell cycle, apoptosis, DNA repair, stress resistance, and metabolism. FOXO proteins are negatively regulated by the phosphatidylinositol 3-kinase-Akt signaling pathway, which is activated by growth factors and cytokines. Recent studies indicate that the activities of FOXO proteins are also regulated by oxidative stress, which induces their phosphorylation, translocation to the nucleus, and acetylation-deacetylation. Similar to the tumor suppressor p53, FOXO is activated by stress and induces the expression of genes that contribute to cell-cycle arrest, s µggesting that it also functions as a tumor suppressor.
Other Names:
FOXO3A , 602681 , O43524 , AF6q21 , DKFZp781A0677 , FKHRL1 , FKHRL1P2 , MGC12739 , MGC31925
Primary Accession: O43524
Gene Name: FOXO3 (HGNC:3821)
Gene ID: 2309
Concentration (mg/ml): 0.2 mg/ml
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