FOXO3A polyclonal, anti-human, rat

Quantity: 100 µg

Background:
Forkhead box O3, also known as FKHRL1 or FOXO3a, is a human protein encoded by the FOXO3 gene. FOXO3 belongs to the O subclass of the forkhead family of transcription factors which are characterized by a distinct fork head DNA-binding domain. It is mapped to 6q21. This protein likely functions as a trigger for apoptosis through upregulation of genes necessary for cell death, such as Bim and PUMA, or downregulation of anti-apoptotic proteins such as FLIP. In mammals FOXO3 regulates the resistance of cells to stress by inducing DNA repair and thereby may also affect organismal life span. In addition, it is thought that FOXO3 is also involved in protection from oxidative stress by upregulating antioxidants such as catalase and MnSOD.

Description:
Rabbit IgG polyclonal antibody for Forkhead box protein O3 (FOXO3) detection. Tested with WB, IHC-P in Human, Rat.

Synonyms:
AF6q21 antibody, AF6q21 protein antibody, DKFZp781A0677 antibody, FKHR2 antibody, FKHRL 1 antibody, FKHRL1 antibody, FKHRL1P2 antibody, Forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1 antibody, Forkhead box O3 antibody, Forkhead box O3A antibody, Forkhead box protein O3 antibody, Forkhead box protein O3A antibody, Forkhead Drosophila homolog of in rhabdomyosarcoma like 1 antibody, Forkhead homolog (rhabdomyosarcoma) like 1 antibody, Forkhead in rhabdomyosarcoma like 1 antibody, Forkhead in rhabdomyosarcoma-like 1 antibody, FOX O3A antibody, FOXO2 antibody, foxo3 antibody, FOXO3_HUMAN antibody, FOXO3A antibody, MGC12739 antibody, MGC31925 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human FOXO3A recombinant protein (Position: Q471-G673). Human FOXO3A shares 97% amino acid (aa) sequence identity with mouse FOXO3A.E.coli-derived human FOXO3A recombinant protein (Position: Q471-G673). Human FOXO3A shares 97% amino acid (aa) sequence identity with mouse FOXO3A.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.