FoxO4 (phospho-S197) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4714
Background:
FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.
Alternative Name:
Forkhead box protein O4, Fork head domain transcription factor AFX1, AFX, AFX1, MLLT7, FOXO4
Application Dilution: IHC: 1:50~1:200
Specificity: p-FoxO4 (S197) polyclonal antibody detects endogenous levels of FoxO4 protein only when phosphorylated at Ser197.
Immunogen:
Synthetic phosphopeptide derived from human FoxO4 around the phosphorylation site of Serine 197.
MW: ~ 55, 70 kDa
Swis Prot.: P98177
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.
Alternative Name:
Forkhead box protein O4, Fork head domain transcription factor AFX1, AFX, AFX1, MLLT7, FOXO4
Application Dilution: IHC: 1:50~1:200
Specificity: p-FoxO4 (S197) polyclonal antibody detects endogenous levels of FoxO4 protein only when phosphorylated at Ser197.
Immunogen:
Synthetic phosphopeptide derived from human FoxO4 around the phosphorylation site of Serine 197.
MW: ~ 55, 70 kDa
Swis Prot.: P98177
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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