FOXP1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
FOXP1("forkhead box P1") is a gene that is necessary for the proper development of the brain and lung in mammals. It is a member of the large FOX family of transcription factors. This gene belongs to subfamily P of the forkhead box(FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region(3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. It was shown that the embryonic stem cell(ESC)-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency, including OCT4, NANOG, NR5A2, and GDF3, while concomitantly repressing genes required for ESC differentiation. This isoform also promotes the maintenance of ESC pluripotency and contributes to efficient reprogramming of somatic cells into induced pluripotent stem cells. These results reveal a pivotal role for an Alternative splicing event in the regulation of pluripotency through the control of critical ESC-specific transcriptional programs(2).

Description:
Rabbit IgG polyclonal antibody for Forkhead box protein P1 (FOXP1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
12CC4 antibody, FLJ23741 antibody, Fork head related protein like B antibody, Forkhead box P1 antibody, Forkhead box protein P1 antibody, FOX P1 antibody, FOXP 1 antibody, foxp1 antibody, FOXP1_HUMAN antibody, Glutamine rich factor 1 antibody, hFKH1B antibody, HSPC215 antibody, MGC12942 antibody, MGC88572 antibody, MGC99551 antibody, QRF 1 antibody, QRF1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human FOXP1(657-677aa HSPDFDHDRDYEDEPVNEDME),identical to the related rat and mouse sequences.A synthetic peptide corresponding to a sequence at the C-terminus of human FOXP1(657-677aa HSPDFDHDRDYEDEPVNEDME),identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.