FR-α (Y80) polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS3861
Background:
The folate receptors consist of five members, α, β, γ, γ’ (which is produced by alternative splicing) and δ. β-FR is attached to the membrane by a GPI anchor and is expressed in malignant tissues of epithelial and nonepithelial origin. γ-FR is expressed in tissues of hematopoietic origin, such as spleen, thymus and bone marrow. The expression pattern of δ-FR is elusive, which suggests that it is highly restricted both spatially and temporally. The α isoform of the folate receptor is used as a highly selective tumor marker and may be targeted for the delivery of therapeutic compounds to tumor cells by coupling to derivatives of folic acid.
Alternative Name:
Folate receptor alpha, Folate receptor-α, FRα, FR-alpha, Adult folate-binding protein, FBP, Folate receptor 1, Folate receptor, adult, KB cells FBP, Ovarian tumor-associated antigen MOv18, FOLR1, FOLR
Application Dilution: WB: 1:500~1:1000
Specificity: FR-α (Y80) polyclonal antibody detects endogenous levels of FR-α (Y80) protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 60-110 of Human FR-α.
MW: ~ 34 kDa
Swis Prot.: P15328
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The folate receptors consist of five members, α, β, γ, γ’ (which is produced by alternative splicing) and δ. β-FR is attached to the membrane by a GPI anchor and is expressed in malignant tissues of epithelial and nonepithelial origin. γ-FR is expressed in tissues of hematopoietic origin, such as spleen, thymus and bone marrow. The expression pattern of δ-FR is elusive, which suggests that it is highly restricted both spatially and temporally. The α isoform of the folate receptor is used as a highly selective tumor marker and may be targeted for the delivery of therapeutic compounds to tumor cells by coupling to derivatives of folic acid.
Alternative Name:
Folate receptor alpha, Folate receptor-α, FRα, FR-alpha, Adult folate-binding protein, FBP, Folate receptor 1, Folate receptor, adult, KB cells FBP, Ovarian tumor-associated antigen MOv18, FOLR1, FOLR
Application Dilution: WB: 1:500~1:1000
Specificity: FR-α (Y80) polyclonal antibody detects endogenous levels of FR-α (Y80) protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 60-110 of Human FR-α.
MW: ~ 34 kDa
Swis Prot.: P15328
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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