FRS2 (phospho-Y436) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS64157
Background:
FRS2 (also designated SNT or p90) is a lipid-anchored docking protein that becomes tyrosine phosphorylated in response to FGF or NGF stimulation and subsequently binds to GRB2/Sos complexes. The GRB2 adapter protein links receptor tyrosine kinases to the Ras/MAPK signaling pathway but does not interact directly with FGF receptors. FRS2 thus provides a link between activation of FGF and NGF receptors and the Ras/MAPK pathway. FRS2 contains four Grb2 binding sites, a myristylation sequence and a PTP domain. Myristylation of FRS2 is essential for membrane localization, tyrosine phosphorylation, GRB2/Sos recruitment and MAPK activation . The function of FRS2 in FGF receptor signaling is analogous to that of IRS1 in response to insulin receptor stimulation .
Alternative Name:
Fibroblast growth factor receptor substrate 2, FGFR substrate 2, FGFR-signaling adaptor SNT, Suc1-associated neurotrophic factor target 1, SNT-1, FRS2
Application Dilution: WB: 1:500~1:1000
Specificity: p-FRS2 (Y436) polyclonal antibody detects endogenous levels of FRS2 protein only when phosphorylated at Tyr436.
Immunogen:
Synthetic phosphopeptide derived from human FRS2 around the phosphorylation site of Tyrosine 436.
MW: ~ 57 kDa
Swis Prot.: Q8WU20
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
FRS2 (also designated SNT or p90) is a lipid-anchored docking protein that becomes tyrosine phosphorylated in response to FGF or NGF stimulation and subsequently binds to GRB2/Sos complexes. The GRB2 adapter protein links receptor tyrosine kinases to the Ras/MAPK signaling pathway but does not interact directly with FGF receptors. FRS2 thus provides a link between activation of FGF and NGF receptors and the Ras/MAPK pathway. FRS2 contains four Grb2 binding sites, a myristylation sequence and a PTP domain. Myristylation of FRS2 is essential for membrane localization, tyrosine phosphorylation, GRB2/Sos recruitment and MAPK activation . The function of FRS2 in FGF receptor signaling is analogous to that of IRS1 in response to insulin receptor stimulation .
Alternative Name:
Fibroblast growth factor receptor substrate 2, FGFR substrate 2, FGFR-signaling adaptor SNT, Suc1-associated neurotrophic factor target 1, SNT-1, FRS2
Application Dilution: WB: 1:500~1:1000
Specificity: p-FRS2 (Y436) polyclonal antibody detects endogenous levels of FRS2 protein only when phosphorylated at Tyr436.
Immunogen:
Synthetic phosphopeptide derived from human FRS2 around the phosphorylation site of Tyrosine 436.
MW: ~ 57 kDa
Swis Prot.: Q8WU20
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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