FRS2 polyclonal, anti-human, mouse, rat antibody
€275.00
In stock
SKU
AC-ABV10647-100
Catalog Number: AC-ABV10647-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
Fibroblast growth factor receptor substrate 2 (FRS2) is a 70-90kDA member of the FSR family of lipid-anchored docking protein. FRS2 contains Grb2 binding sites, a myristylation sequence and a PTP domain. Activation of FGFR leads to tyrosine phosphorylation of FRS2 and the binding of phosphorylated FRS2 to GRB2/SOS complexes. Once phosphorylated, FRS2 recruits SH2 domain-containing proteins including Grb2 and SHP-2 mediating downstream signalling. FRS2 thus, acts as an intermediary between FGF and Trk receptors that links receptor tyrosine kinase to Ras/MAPK signaling pathway.
Other Names:
FRS2 , FRS2A , FRS2alpha , SNT, SNT-1 , SNT
Primary Accession: Q8WU20
Other Accession: NP_006645.3
Gene Name: FRS2
Gene ID: 10818
Concentration (mg/ml): 0.5 mg/ml
Fibroblast growth factor receptor substrate 2 (FRS2) is a 70-90kDA member of the FSR family of lipid-anchored docking protein. FRS2 contains Grb2 binding sites, a myristylation sequence and a PTP domain. Activation of FGFR leads to tyrosine phosphorylation of FRS2 and the binding of phosphorylated FRS2 to GRB2/SOS complexes. Once phosphorylated, FRS2 recruits SH2 domain-containing proteins including Grb2 and SHP-2 mediating downstream signalling. FRS2 thus, acts as an intermediary between FGF and Trk receptors that links receptor tyrosine kinase to Ras/MAPK signaling pathway.
Other Names:
FRS2 , FRS2A , FRS2alpha , SNT, SNT-1 , SNT
Primary Accession: Q8WU20
Other Accession: NP_006645.3
Gene Name: FRS2
Gene ID: 10818
Concentration (mg/ml): 0.5 mg/ml
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