FRZB polyclonal, anti-human

Quantity: 100 µg

Background:
FRZB is also known as FRE or OS1. The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. FRZB is a Wnt-binding protein especially important in embryonic development. It is a competitor for the cell-surface G-protein receptor Frizzled. FRZB is localized in the extracellular plasma membrane. Unlike frizzled, frzb lacks the 7 transmembrane domains normally found in G-protein-coupled receptors. It is still considered a homolog of frizzled because it contains a Cysteine Rich Domain (CRD), and because of its intracellular C-terminus which is crucial for signaling.

Description:
Rabbit IgG polyclonal antibody for Secreted frizzled-related protein 3 (FRZB) detection. Tested with WB, ELISA in Human.

Synonyms:
FIZ antibody, FRE antibody, Frezzled antibody, Fritz antibody, Frizzled-related protein 1 antibody, FRP antibody, FrzB 1 antibody, FRZB antibody, FRZB1 antibody, OTTMUSP00000014350 antibody, RP23-33L19.1 antibody, Secreted frizzled related protein 3 [Precursor] antibody, Secreted frizzled related sequence protein 3 antibody, sFRP 3 antibody, SFRP antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human FRZB recombinant protein (Position: E176-N325). Human FRZB shares 90% amino acid (aa) sequence identity with mouse FRZB.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, ELISA

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.