FSH-R polyclonal, anti-human, mouse, rat

Protein Family: Receptors and Channels

Pathway and Disease: Endocrine System, Signaling Molecules and Interaction

Description:
Follicle-stimulating hormone receptor (FSH-R) is the receptor for follicle-stimulating hormone (FSH). The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in FSH-R are a cause of ovarian dysgenesis type 1 (ODG1), also known as premature ovarian failure, gonadal dysgenesis XX type, XX gonadal dysgenesis (XXGD), hereditary hypergonadotropic ovarian failure, or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).

Alternate Names: FSH-R, Follicle-stimulating hormone receptor, Follitropin receptor, FSHR, LGR1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P23945

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human FSH-R.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.