FSHR polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5724
Background:
Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G-protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its α and β subunits. While the α subunit of FSH is involved in the binding of FSH to the receptor, the β subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG). In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome; a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.
Alternative Name:
Follicle-stimulating hormone receptor, FSH-R, Follitropin receptor, LGR1
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200, ICC: 1:50~1:200
Specificity: FSHR polyclonal antibody detects endogenous levels of FSHR protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 330-375 of Human FSHR.
MW: ~ 78 kDa
Swis Prot.: P23945
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G-protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its α and β subunits. While the α subunit of FSH is involved in the binding of FSH to the receptor, the β subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG). In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome; a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.
Alternative Name:
Follicle-stimulating hormone receptor, FSH-R, Follitropin receptor, LGR1
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200, ICC: 1:50~1:200
Specificity: FSHR polyclonal antibody detects endogenous levels of FSHR protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 330-375 of Human FSHR.
MW: ~ 78 kDa
Swis Prot.: P23945
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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