FTO polyclonal, anti-human

Background:
FTO, also known as Fatso or KIAA1752, is a 505 amino acid protein that has an N-terminal nuclear localization signal. Expressed in a variety of tissues, with highest levels present in brain and pancreatic tissue, Fatso exists as four alternatively spliced isoforms, one of which is associated with a predisposition to childhood and adult obesity. Due to its involvement in the development of obesity, Fatso is associated with an increased BMI and may be involved in the pathogenesis of type 2 diabetes. The gene encoding Fatso maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.

Alternative Name:
FTO, KIAA1752, AlkB homolog 9, ALKBH9, Alpha-ketoglutarate-dependent dioxygenase FTO, AW743446, Fat mass and obesity-associated protein, FATSO, MOUSE, HOMOLOG OF, Fto, FTO, GDFD, KIAA1752, mKIAA1752, Protein fatso,

Application Dilution:
WB:1:500-1:2,000
ICC/IF:1:50-1:200
IHC:1:50-1:200

Specificity: FTO polyclonal antibody detects endogenous levels of FTO protein.

Immunogen:
Recombinant protein

Swiss-Prot: Q9C0B1(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.