FTS antibody (clone 2A11), anti-human
€435.00
In stock
SKU
AC-AT2116a
Catalog Number: AC-AT2116a
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB
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Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB
Request Information AC-AT2116a">Request Information
Background:
The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
Other Names:
AKT-interacting protein, Ft1, Fused toes protein homolog, AKTIP, FTS
Antigen Type:
Recombinant Protein
Gene Name: AKTIP (HGNC:16710)
Gene ID: 64400
NCBI Accession: NP_001012398.1;NP_071921.1
Primary Accession: Q9H8T0
Other Accession: BC001134
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
Other Names:
AKT-interacting protein, Ft1, Fused toes protein homolog, AKTIP, FTS
Antigen Type:
Recombinant Protein
Gene Name: AKTIP (HGNC:16710)
Gene ID: 64400
NCBI Accession: NP_001012398.1;NP_071921.1
Primary Accession: Q9H8T0
Other Accession: BC001134
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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