FUK (Q26) polyclonal, anti-human, mouse, rat

Background:
Blood group antigen recognition, metastasis and inflammation utilize fucose, a sugar found in glycoproteins and glycolipids. Fucokinase, also designated L-fucose kinase or FUK, is a 1,084 amino acid enzyme that plays a role in the salvage pathway of fucose reutilization. A member of the GHMP kinase family, Fucokinase exists as two alternative splice variants and catalyzes L-fucose phosphorylation to form β-L-fucose 1-phosphate. The gene encoding Fucokinase maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn’s disease, which is a gastrointestinal inflammatory condition.

Alternative Name:
L-fucose kinase, Fucokinase, FUK

Application Dilution:
WB: 1:500~1:1000

Specificity: Fucokinase (Q26) polyclonal antibody detects endogenous levels of Fucokinase protein.

Immunogen:
Synthetic peptide, corresponding to amino acids 10-70 of Human Fucokinase.

MW: ~ 118 kDa

Swiss-Prot: Q8N0W3

Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.