Furin polyclonal, anti-human

Quantity: 100 µg

Background:
Furin(Fur), also known as PACE, is a protein that in humans is encoded by the FURIN gene. The protein encoded by this gene is an enzyme which belongs to the subtilisin-like proprotein convertase family. The Furin gene is located approximately 1 kb upstream of the FES gene on chromosome 15q25-q26. This gene is thought to play a role in tumor progression. Furin is one of the proteases responsible for the proteolytic cleavage of HIV envelope polyprotein precursor gp160 to gp120 and gp41 prior to viral assembly. Furin is enriched in the Golgi apparatus, where it functions to cleave other proteins into their mature/active forms. Expression of furin in T-cells is required for maintenance of peripheral immune tolerance.

Description:
Rabbit IgG polyclonal antibody for Furin (FURIN) detection. Tested with WB in Human.

Synonyms:
Dibasic processing enzyme antibody, Dibasic-processing enzyme antibody, FES upstream region antibody, FUR antibody, FURIN antibody, Furin membrane associated receptor protein antibody, FURIN_HUMAN antibody, PACE antibody, Paired basic amino acid residue cleaving enzyme antibody, Paired basic amino acid residue-cleaving enzyme antibody, PCSK3 antibody, Proprotein convertase subtilisin/kexin type 3 antibody, SPC1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Furin recombinant protein (Position: T591-L794). Human Furin shares 88% amino acid (aa) sequence identity with both mouse and rat Furin.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.