Fusion glycoprotein F0 polyclonal, anti-avian avulavirus 1

Background:
During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participate in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.

Alternative Name:
F, F, Fusion glycoprotein F0, Protein F, RSV Fusion (F) Glycoprotein,

Application Dilution:
WB:1:500-1,000
ELISA:1:5,000-1:10,000

Specificity: Fusion glycoprotein F0 polyclonal antibody detects endogenous levels of Fusion glycoprotein F0 protein.

Immunogen:
Peptide

MW: 59 kDa

Swiss-Prot: W8CLH7

Purification & Purity:
Peptide affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.