FXL18 Rabbit polyclonal antibody, anti-human, mouse, rat

Background:
The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7| a protein that induces mitotic arrest| by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family| such as FBXL18| are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box| and they interact with ubiquitination targets through other protein interaction domains.

Research Area: Cell biology, Epigenetics and nuclear signaling

Synonyms: FXL18

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year