FXR polyclonal, anti-human, mouse, rat
€469.00
In stock
SKU
252165
Protein Family: Receptors and Channels, Transcription Factors
Pathway and Disease: Transcription
Description:
Bile acid receptor (FXR) is a ligand-activated transcription factor. FXR is a receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. FXR represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression via two distinct mechanisms. FXR activates the intestinal bile acid-binding protein (IBABP). FXR activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
Alternate Names: Bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14
Application Notes: E: 1:1,000-1:5,000; WB: 1:100-1:500
Accession No.: Q96RI1
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human FXR.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Transcription
Description:
Bile acid receptor (FXR) is a ligand-activated transcription factor. FXR is a receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. FXR represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression via two distinct mechanisms. FXR activates the intestinal bile acid-binding protein (IBABP). FXR activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
Alternate Names: Bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14
Application Notes: E: 1:1,000-1:5,000; WB: 1:100-1:500
Accession No.: Q96RI1
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human FXR.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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