FZD6 polyclonal, anti-human, mouse

Background:
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.

Synonyms: FZ-6, FZ6, HFZ6, NDNC10

Cellular Location: Apical cell membrane Cell membrane Cell surface Cytoplasmic vesicle membrane Membrane Multi-pass membrane protein

Immunogen:
Recombinant protein of human FZD6

Gene Symbol: FZD6

Gene ID: 8323

Swiss prot: O60353

Calculated MW: 79kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.