FZD6 polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP11009c
Catalog Number: AC-AP11009c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB25725
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB25725
Applications: WB
Datasheet
Request Information
Background:
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants.
Other Names:
Frizzled-6, Fz-6, hFz6, FZD6
Target/Specificity:
This FZD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-520 amino acids from the Central region of human FZD6.
Antigen Region:
493-520
Antigen Type: Synthetic Peptide
Gene Name: FZD6
Gene ID: 8323
Primary Accession: O60353
NCBI Accession: NP_001158087.1;NP_001158088.1;NP_003497.2
Other Accession: Q61089; NP_001158087.1; NP_003497.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants.
Other Names:
Frizzled-6, Fz-6, hFz6, FZD6
Target/Specificity:
This FZD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-520 amino acids from the Central region of human FZD6.
Antigen Region:
493-520
Antigen Type: Synthetic Peptide
Gene Name: FZD6
Gene ID: 8323
Primary Accession: O60353
NCBI Accession: NP_001158087.1;NP_001158088.1;NP_003497.2
Other Accession: Q61089; NP_001158087.1; NP_003497.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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