FZR monoclonal, anti-human
€0.00
In stock
SKU
AC-AM8522b
Catalog Number: AC-AM8522b
Size: 50 µl, 200 µl
Isotype: mouse IgG1,k
Clone Name: 1621CT637.76.67
Applications: WB
Datasheet
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Size: 50 µl, 200 µl
Isotype: mouse IgG1,k
Clone Name: 1621CT637.76.67
Applications: WB
Datasheet
Request Information
Background:
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Other Names:
Fizzy-related protein homolog, Fzr, CDC20-like protein 1, Cdh1/Hct1 homolog, hCDH1, FZR1, CDH1, FYR, FZR, KIAA1242
Target/Specificity:
This FZR antibody is generated from a mouse immunized with a recombinant protein between1-496 amino acids from human FZR.
Antigen Type: Recombinant Protein
Gene Name: FZR1 (HGNC:24824)
Gene ID: 51343
Primary Accession: Q9UM11
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Other Names:
Fizzy-related protein homolog, Fzr, CDC20-like protein 1, Cdh1/Hct1 homolog, hCDH1, FZR1, CDH1, FYR, FZR, KIAA1242
Target/Specificity:
This FZR antibody is generated from a mouse immunized with a recombinant protein between1-496 amino acids from human FZR.
Antigen Type: Recombinant Protein
Gene Name: FZR1 (HGNC:24824)
Gene ID: 51343
Primary Accession: Q9UM11
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
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